histone methyltransferase — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T8201	Gambogenic acid		Histone Methyltransferase
	Gambogenic acid is a natural product,is an effective inhibitor of EZH2,with anticancer activity.		Histone Methyltransferase
T8548	Metoprine		Histone Methyltransferase , Antifolate , Histamine Receptor
	Metoprine is a potent inhibitor of histamine N-methyltransferase (HMT), with potential antineoplastic activity.		Histone Methyltransferase , Antifolate , Histamine Receptor
T6803	Chaetocin		Histone Methyltransferase , Antibacterial , Antibiotic
	Chaetocin, a natural product from Chaetomium species, is a histone methyltransferase inhibitor with IC50 of 0.8 μM, 2.5 μM and 3 μM for dSU(VAR)3-9, mouse G9a and Neurospora crassa DIM5, respectively.		Histone Methyltransferase , Antibacterial , Antibiotic
T8381	Amodiaquine		Others , Histone Methyltransferase , Parasite
	Amodiaquine is a synthetic aminoquinoline, used to treat malaria.		Others , Histone Methyltransferase , Parasite
T2435	EPZ011989		Histone Methyltransferase
	EPZ011989 is a effective, specific orally bioavailable EZH2 inhibitor with Ki < 3 nM for EZH2 Y646 and EZH2 wt; 15-fold selectivity over EZH1 and >3000-fold selectivity over other HMTase.		Histone Methyltransferase
TQ0100	AZ505		Histone Methyltransferase
	AZ505 is an effective and specific SMYD2 inhibitor (IC50: 0.12 μM).		Histone Methyltransferase
T15194	EBI-2511		Histone Methyltransferase
	EBI-2511 is a highly potent and orally active inhibitor of EZH2 (IC50: 6 nM in Pfeffiera cell lines).		Histone Methyltransferase
T2097	C-7280948	C7280948	Histone Methyltransferase
	C-7280948 is a PRMT1 inhibitor.		Histone Methyltransferase
T1905	EPZ005687		Histone Methyltransferase
	EPZ005687 is a potent and selective inhibitor of EZH2.		Histone Methyltransferase
T6900	MS023		Histone Methyltransferase
	MS023 is a potent, selective, and cell-active Type I PRMT inhibitor with IC50 of 30 nM, 119 nM, 83 nM, 4 nM, and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6 and PRMT8, respectively.		Histone Methyltransferase
T3084	SGC707		Histone Methyltransferase
	SGC707 is a potent, selective, and cell-active allosteric inhibitor of PRMT3.		Histone Methyltransferase
T7089	SGC2085		Histone Methyltransferase
	SGC2085 is an effective and selective coactivator-associated arginine methyltransferase 1 (CARM1) inhibitor (IC50: 50 nM).		Histone Methyltransferase
T7403	BAY-598		Histone Methyltransferase
	BAY-598 is a selective inhibitor of SMYD2 with IC50 values of 27 nM.		Histone Methyltransferase
T1775	GSK503		Histone Methyltransferase
	GSK-503, a potent EZH2 inhibitor, has potential antitumor activity.		Histone Methyltransferase
T3081	EPZ004777		Apoptosis , Histone Methyltransferase
	EPZ004777 is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM.		Apoptosis , Histone Methyltransferase
T15624	JNJ-64619178		Histone Methyltransferase
	JNJ-64619178 is a selective, orally active, and pseudo-irreversible inhibitor of protein arginine methyltransferase 5 (IC50: 0.14 nM). It has effective activity In lung cancer.		Histone Methyltransferase
T6059	GSK343		Histone Methyltransferase , Autophagy
	GSK343, a specific and effective EZH2 inhibitor (IC50=4 nM), exhibits 60 fold specificity activity against EZH1, and >1000 fold specificity activity against other histone methyltransferases.		Histone Methyltransferase , Autophagy
T3057	UNC1999		Histone Methyltransferase , Autophagy
	UNC1999 is a orally bioavailable, effective and specific inhibitor of EZH2 (IC50=2 nM) and EZH1 (IC50=45).		Histone Methyltransferase , Autophagy
T6879	LLY-507	LLY507,LLY 507	Histone Methyltransferase
	LLY-507 is an effective, cell-active, and specific inhibitor of protein-lysine Methyltransferase SMYD2.		Histone Methyltransferase
T4021	UNC3866		Histone Methyltransferase
	UNC3866 is a potent antagonist of the CBX7-H3 interaction as determined by AlphaScreen.		Histone Methyltransferase